C9orf72 Proteins Regulate Autophagy and Undergo Autophagosomal or Proteasomal Degradation in a Cell Type-Dependent Manner

C9orf72 Proteins Regulate Autophagy and Undergo Autophagosomal or Proteasomal Degradation in a Cell Type-Dependent Manner

Dysfunctional autophagy or ubiquitin-proteasome system (UPS) are suggested to underlie abnormal protein aggregation in neurodegenerative diseases. Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS)-associated <i>C9orf72</i> is implicated in autophagy, but whether it ac...

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Bibliographic Details
Main Authors: Stina Leskelä, Nadine Huber, Hannah Rostalski, Teemu Natunen, Anne M. Remes, Mari Takalo, Mikko Hiltunen, Annakaisa Haapasalo
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Cells
Subjects:
amyotrophic lateral sclerosis
autophagy
<i>c9orf72</i>
frontotemporal dementia
proteasomal degradation
ubiquitin-proteasome system
Online Access:https://www.mdpi.com/2073-4409/8/10/1233

Internet

https://www.mdpi.com/2073-4409/8/10/1233

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