Discovery of novel indene-based hybrids as breast cancer inhibitors targeting Hsp90: Synthesis, bio-evaluation and molecular docking study

Discovery of novel indene-based hybrids as breast cancer inhibitors targeting Hsp90: Synthesis, bio-evaluation and molecular docking study

Inhibition of Heat-shock protein 90 (Hsp90) is considered an attractive route in fighting against cancer proliferation. Herein, new indene derivatives targeting Hsp90 were synthesized, and biologically evaluated. The new series of indeno-pyrimidine and indeno-pyridine were synthesized from the react...

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Bibliographic Details
Main Authors: Amal M. Alosaimy, Amr S. Abouzied, Amani M. R. Alsaedi, Ahmed Alafnan, Abdulwahab Alamri, Mubarak A. Alamri, Mohammed Khaled Bin Break, Rehab Sabour, Thoraya A. Farghaly
Format: Article
Language:English
Published: Elsevier 2023-04-01
Series:Arabian Journal of Chemistry
Subjects:
Enaminones
Hetero-amines
Aminopyrazoles
Aminotriazoles
Breast cancer inhibitors
Online Access:http://www.sciencedirect.com/science/article/pii/S1878535223000308

Internet

http://www.sciencedirect.com/science/article/pii/S1878535223000308

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