Discovery of novel indene-based hybrids as breast cancer inhibitors targeting Hsp90: Synthesis, bio-evaluation and molecular docking study
Inhibition of Heat-shock protein 90 (Hsp90) is considered an attractive route in fighting against cancer proliferation. Herein, new indene derivatives targeting Hsp90 were synthesized, and biologically evaluated. The new series of indeno-pyrimidine and indeno-pyridine were synthesized from the react...
Main Authors: | Amal M. Alosaimy, Amr S. Abouzied, Amani M. R. Alsaedi, Ahmed Alafnan, Abdulwahab Alamri, Mubarak A. Alamri, Mohammed Khaled Bin Break, Rehab Sabour, Thoraya A. Farghaly |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2023-04-01
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Series: | Arabian Journal of Chemistry |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S1878535223000308 |
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