K27-linked RORγt ubiquitination by Nedd4 potentiates Th17-mediated autoimmunity
Abstract Background The HECT E3 ubiquitin ligase Nedd4 has been shown to positively regulate T cell responses, but its role in T helper (Th) cell differentiation and autoimmunity is unknown. Th17 cells are believed to play a pivotal role in the development and pathogenesis of autoimmune diseases. Ne...
Glavni autori: | , , , , , , , , , , , , , , , , , , , , |
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Format: | Članak |
Jezik: | English |
Izdano: |
BMC
2025-02-01
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Serija: | Journal of Biomedical Science |
Teme: | |
Online pristup: | https://doi.org/10.1186/s12929-025-01120-2 |