A library approach for the de novo high-throughput isolation of humanized VHH domains with favorable developability properties following camelid immunization

A library approach for the de novo high-throughput isolation of humanized VHH domains with favorable developability properties following camelid immunization

ABSTRACTIn this study, we generated a novel library approach for high throughput de novo identification of humanized single-domain antibodies following camelid immunization. To achieve this, VHH-derived complementarity-determining regions-3 (CDR3s) obtained from an immunized llama (Lama glama) were...

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Bibliographic Details
Main Authors: Paul Arras, Han Byul Yoo, Lukas Pekar, Christian Schröter, Thomas Clarke, Simon Krah, Daniel Klewinghaus, Vanessa Siegmund, Andreas Evers, Stefan Zielonka
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:mAbs
Subjects:
Antibody display
antibody engineering
humanization
in silico developability
library design
NGS
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2023.2261149

Internet

https://www.tandfonline.com/doi/10.1080/19420862.2023.2261149

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