Multifunctional nanocomposites DDMplusAF inhibit the proliferation and enhance the radiotherapy of breast cancer cells via modulating tumor-promoting factors and metabolic reprogramming

Multifunctional nanocomposites DDMplusAF inhibit the proliferation and enhance the radiotherapy of breast cancer cells via modulating tumor-promoting factors and metabolic reprogramming

Abstract Background Tumor-promoting factors (TPF) and metabolic reprogramming are hallmarks of cancer cell growth. This study is designed to combine the newly synthesized two nanocomposites DDM (HA-FA-2DG@DCA@MgO) and AF (HA-FA-Amygdaline@Fe2O3) with fractionated doses of radiotherapy (6 Gy-FDR; fra...

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Bibliographic Details
Main Authors: Noura M. Thabet, Mohamed K. Abdel-Rafei, Gharieb S. El-Sayyad, Mohamed Abd Elkodous, Adel Shaaban, Yi-Chun Du, Laila Ahmed Rashed, Mostafa A. Askar
Format: Article
Language:English
Published: BMC 2022-05-01
Series:Cancer Nanotechnology
Subjects:
Nanocomposites
Targeted therapy
Radiotherapy
TPF
Metabolic reprogramming
Glycolysis
Online Access:https://doi.org/10.1186/s12645-022-00122-1

Internet

https://doi.org/10.1186/s12645-022-00122-1

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