Endoplasmic Reticulum Stress Mediated MDRV p10.8 Protein-Induced Cell Cycle Arrest and Apoptosis Through the PERK/eIF2α Pathway

Endoplasmic Reticulum Stress Mediated MDRV p10.8 Protein-Induced Cell Cycle Arrest and Apoptosis Through the PERK/eIF2α Pathway

In this study, the mechanism of Muscovy duck reovirus (MDRV) p10.8 protein-induced pathogenesis was investigated, with a focus on endoplasmic reticulum (ER) stress. In chicken embryo fibroblasts cell lines (DF1), pCI-neo-flg-p10.8 protein transfection increased the phosphorylation (p-) levels of PER...

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Bibliographic Details
Main Authors: Quanxi Wang, Xiaoqin Yuan, Yuan Chen, Qingli Zheng, Lihui Xu, Yijian Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Microbiology
Subjects:
endoplasmic reticulum stress
MDRV
apoptosis
cell cycle arrest
PERK
eIF2α
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2018.01327/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2018.01327/full

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