Sequence Properties of an Intramolecular Interaction that Inhibits p53 DNA Binding

Sequence Properties of an Intramolecular Interaction that Inhibits p53 DNA Binding

An intramolecular interaction between the p53 transactivation and DNA binding domains inhibits DNA binding. To study this autoinhibition, we used a fragment of p53, referred to as ND WT, containing the N-terminal transactivation domains (TAD1 and TAD2), a proline rich region (PRR), and the DNA bindi...

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Bibliographic Details
Main Authors: Emily Gregory, Gary W. Daughdrill
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Biomolecules
Subjects:
tumor suppressor p53
intrinsically disordered proteins
intramolecular interaction
salt-dependent binding affinity
counterion condensation theory
DNA binding
Online Access:https://www.mdpi.com/2218-273X/12/11/1558

Internet

https://www.mdpi.com/2218-273X/12/11/1558

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