Hyperactive Behavior and Altered Brain Morphology in Adult Complement C3a Receptor Deficient Mice

The C3a receptor (C3aR) is a seven trans-membrane domain G-protein coupled receptor with a range of immune modulatory functions. C3aR is activated by the third complement component (C3) activation derived peptide C3a and a neuropeptide TLQP-21. In the central nervous system (CNS), C3aR is expressed...

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Bibliographic Details
Main Authors: Andrea Pozo-Rodrigálvarez, Roosa Ollaranta, Jenny Skoog, Milos Pekny, Marcela Pekna
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Immunology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.604812/full