Multiple Mutations in the Non-Ordered Red Ω-Loop Enhance the Membrane-Permeabilizing and Peroxidase-like Activity of Cytochrome <i>c</i>

Multiple Mutations in the Non-Ordered Red Ω-Loop Enhance the Membrane-Permeabilizing and Peroxidase-like Activity of Cytochrome <i>c</i>

A key event in the cytochrome <i>c</i>-dependent apoptotic pathway is the permeabilization of the outer mitochondrial membrane, resulting in the release of various apoptogenic factors, including cytochrome <i>c</i>, into the cytosol. It is believed that the permeabilization o...

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Bibliographic Details
Main Authors: Rita V. Chertkova, Alexander M. Firsov, Nadezda A. Brazhe, Evelina I. Nikelshparg, Zhanna V. Bochkova, Tatyana V. Bryantseva, Marina A. Semenova, Adil A. Baizhumanov, Elena A. Kotova, Mikhail P. Kirpichnikov, Georgy V. Maksimov, Yuriy N. Antonenko, Dmitry A. Dolgikh
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Biomolecules
Subjects:
mitochondrial cytochrome <i>c</i>
heme
red Ω-loop of cytochrome <i>c</i>
liposome leakage
cardiolipin
peroxidase activity
Online Access:https://www.mdpi.com/2218-273X/12/5/665

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https://www.mdpi.com/2218-273X/12/5/665

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