Adipocytic Glutamine Synthetase Upregulation via Altered Histone Methylation Promotes 5FU Chemoresistance in Peritoneal Carcinomatosis of Colorectal Cancer

Adipocytic Glutamine Synthetase Upregulation via Altered Histone Methylation Promotes 5FU Chemoresistance in Peritoneal Carcinomatosis of Colorectal Cancer

The development of resistance to 5-fluorouracil (5FU) chemotherapy is a major handicap for sustained effective treatment in peritoneal carcinomatosis (PC) of colorectal cancer (CRC). Metabolic reprogramming of adipocytes, a component of the tumor microenvironment and the main composition of peritone...

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Bibliographic Details
Main Authors: Xuan Zhang, Qing Li, Aibei Du, Yifei Li, Qing Shi, Yanrong Chen, Yang Zhao, Bin Wang, Feng Pan
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Oncology
Subjects:
peritoneal carcinomatosis
colorectal cancer
chemoresistance
glutamine synthetase
histone methylation
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.748730/full

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https://www.frontiersin.org/articles/10.3389/fonc.2021.748730/full

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