Single-molecule protein identification by sub-nanopore sensors.

Recent advances in top-down mass spectrometry enabled identification of intact proteins, but this technology still faces challenges. For example, top-down mass spectrometry suffers from a lack of sensitivity since the ion counts for a single fragmentation event are often low. In contrast, nanopore t...

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Bibliographic Details
Main Authors: Mikhail Kolmogorov, Eamonn Kennedy, Zhuxin Dong, Gregory Timp, Pavel A Pevzner
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-05-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC5423552?pdf=render