Single-molecule protein identification by sub-nanopore sensors.
Recent advances in top-down mass spectrometry enabled identification of intact proteins, but this technology still faces challenges. For example, top-down mass spectrometry suffers from a lack of sensitivity since the ion counts for a single fragmentation event are often low. In contrast, nanopore t...
Main Authors: | Mikhail Kolmogorov, Eamonn Kennedy, Zhuxin Dong, Gregory Timp, Pavel A Pevzner |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2017-05-01
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Series: | PLoS Computational Biology |
Online Access: | http://europepmc.org/articles/PMC5423552?pdf=render |
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