Reaction engineering blocks ether cleavage for synthesizing chiral cyclic hemiacetals catalyzed by unspecific peroxygenase

Abstract Hemiacetal compounds are valuable building blocks in synthetic chemistry, but their enzymatic synthesis is limited and often hindered by the instability of hemiacetals in aqueous environments. Here, we show that this challenge can be addressed through reaction engineering by using immobiliz...

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Detalles Bibliográficos
Main Authors: Xiaofeng Han, Fuqiang Chen, Huanhuan Li, Ran Ge, Qianqian Shen, Peigao Duan, Xiang Sheng, Wuyuan Zhang
Formato: Artigo
Idioma:English
Publicado: Nature Portfolio 2024-02-01
Series:Nature Communications
Acceso en liña:https://doi.org/10.1038/s41467-024-45545-z