Newcastle disease virus (NDV) expressing the spike protein of SARS-CoV-2 as a live virus vaccine candidate

Newcastle disease virus (NDV) expressing the spike protein of SARS-CoV-2 as a live virus vaccine candidate

Background: Due to the lack of protective immunity of humans towards the newly emerged SARS-CoV-2, this virus has caused a massive pandemic across the world resulting in hundreds of thousands of deaths. Thus, a vaccine is urgently needed to contain the spread of the virus. Methods: Here, we describe...

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Bibliographic Details
Main Authors: Weina Sun, Sarah R. Leist, Stephen McCroskery, Yonghong Liu, Stefan Slamanig, Justine Oliva, Fatima Amanat, Alexandra Schäfer, Kenneth H. Dinnon, III, Adolfo García-Sastre, Florian Krammer, Ralph S. Baric, Peter Palese
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:EBioMedicine
Subjects:
Viral vector vaccine
Intramuscular administration
Neutralizing antibodies
Mouse-adapted SARS-CoV-2
Live COVID-19 vaccine
Coronavirus vaccine
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396420305089

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http://www.sciencedirect.com/science/article/pii/S2352396420305089

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