In Vivo Inhibition of Marek’s Disease Virus in Transgenic Chickens Expressing Cas9 and gRNA against ICP4

In Vivo Inhibition of Marek’s Disease Virus in Transgenic Chickens Expressing Cas9 and gRNA against ICP4

Marek’s disease (MD), caused by MD herpesvirus (MDV), is an economically important disease in chickens. The efficacy of the existing vaccines against evolving virulent stains may become limited and necessitates the development of novel antiviral strategies to protect poultry from MDV strains with in...

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Bibliographic Details
Main Authors: Arjun Challagulla, Kristie A. Jenkins, Terri E. O’Neil, Shunning Shi, Kirsten R. Morris, Terry G. Wise, Prasad N. Paradkar, Mark L. Tizard, Timothy J. Doran, Karel A. Schat
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Microorganisms
Subjects:
Marek’s disease virus
CRISPR/Cas9
ICP4
transgenic chicken
disease resilience
Online Access:https://www.mdpi.com/2076-2607/9/1/164

Internet

https://www.mdpi.com/2076-2607/9/1/164

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