The LEDGF/p75 Integrase Binding Domain Interactome Contributes to the Survival, Clonogenicity, and Tumorsphere Formation of Docetaxel-Resistant Prostate Cancer Cells

The LEDGF/p75 Integrase Binding Domain Interactome Contributes to the Survival, Clonogenicity, and Tumorsphere Formation of Docetaxel-Resistant Prostate Cancer Cells

Patients with prostate cancer (PCa) receiving docetaxel chemotherapy invariably develop chemoresistance. The transcription co-activator lens epithelium-derived growth factor p75 (LEDGF/p75), also known as DFS70 and PSIP1, is upregulated in several human cancers, including PCa and promotes resistance...

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Bibliographic Details
Main Authors: Greisha L. Ortiz-Hernandez, Evelyn S. Sanchez-Hernandez, Pedro T. Ochoa, Catherine C. Elix, Hossam R. Alkashgari, James R. W. McMullen, Ubaldo Soto, Shannalee R. Martinez, Carlos J. Diaz Osterman, Michael Mahler, Sourav Roy, Carlos A. Casiano
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Cells
Subjects:
autoantibodies
cell survival
chemoresistance
docetaxel
LEDGF/p75
integrase binding domain
Online Access:https://www.mdpi.com/2073-4409/10/10/2723

Internet

https://www.mdpi.com/2073-4409/10/10/2723

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