Differential Effects of the Six Human TAU Isoforms: Somatic Retention of 2N-TAU and Increased Microtubule Number Induced by 4R-TAU

Differential Effects of the Six Human TAU Isoforms: Somatic Retention of 2N-TAU and Increased Microtubule Number Induced by 4R-TAU

In the adult human brain, six isoforms of the microtubule-associated protein TAU are expressed, which result from alternative splicing of exons 2, 3, and 10 of the MAPT gene. These isoforms differ in the number of N-terminal inserts (0N, 1N, 2N) and C-terminal repeat domains (3R or 4R) and are diffe...

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Bibliographic Details
Main Authors: Sarah Bachmann, Michael Bell, Jennifer Klimek, Hans Zempel
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Neuroscience
Subjects:
TAU
MAPT
microtubule-associated proteins
microtubule dynamics
primary neuron cell culture
SH-SY5Y cell line
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2021.643115/full

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https://www.frontiersin.org/articles/10.3389/fnins.2021.643115/full

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