EVALUATION OF THE GENOTOXIC EFFECTS OF MITOMYCIN C ON THE EXAMPLE OF APOE KNOCKOUT MICE
BACKGROUNDMitomycin C (MMC) has a wide spectrum of genotoxicity, including inhibition of DNA synthesis, clastogenesis and mutagenesis. As an immediate-action clastogen requiring exclusively intracellular reductive activation, MMC initiates efficient DNA cross-linking. Most studies are aimed at study...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Ministry of Health of the Russian Federation, Irkutsk State Medical University
2023-09-01
|
| Series: | Байкальский медицинский журнал |
| Subjects: | |
| Online Access: | https://www.bmjour.ru/jour/article/view/83 |