A tumor microenvironment model of chronic lymphocytic leukemia enables drug sensitivity testing to guide precision medicine

A tumor microenvironment model of chronic lymphocytic leukemia enables drug sensitivity testing to guide precision medicine

Abstract The microenvironment of chronic lymphocytic leukemia (CLL) cells in lymph nodes, spleen, and bone marrow provides survival, proliferation, and drug resistance signals. Therapies need to be effective in these compartments, and pre-clinical models of CLL that are used to test drug sensitivity...

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Bibliographic Details
Main Authors: Johanne U. Hermansen, Yanping Yin, Aleksandra Urban, Camilla V. Myklebust, Linda Karlsen, Katrine Melvold, Anders A. Tveita, Kjetil Taskén, Ludvig A. Munthe, Geir E. Tjønnfjord, Sigrid S. Skånland
Format: Article
Language:English
Published: Nature Publishing Group 2023-04-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-023-01426-w

Internet

https://doi.org/10.1038/s41420-023-01426-w

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