Increased immune infiltration and chemokine receptor expression in head and neck epithelial tumors after neoadjuvant immunotherapy with the IRX-2 regimen

Increased immune infiltration and chemokine receptor expression in head and neck epithelial tumors after neoadjuvant immunotherapy with the IRX-2 regimen

IRX-2 is an injectable cancer immunotherapy composed of cytokines purified from stimulated normal-donor peripheral blood mononuclear cells. In a phase 2a trial (n = 27), neoadjuvant IRX-2 significantly increased lymphocyte infiltration (LI) into resected head and neck tumors and was associated with...

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Bibliographic Details
Main Authors: Neil L. Berinstein, Michael McNamara, Ariane Nguyen, James Egan, Gregory T. Wolf
Format: Article
Language:English
Published: Taylor & Francis Group 2018-05-01
Series:OncoImmunology
Subjects:
cytokines
dendritic cells
immunotherapy
head and neck squamous cell carcinoma
t cells
Online Access:http://dx.doi.org/10.1080/2162402X.2017.1423173

Internet

http://dx.doi.org/10.1080/2162402X.2017.1423173

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