Hypothermic Preconditioning of Human Cortical Neurons Requires Proteostatic Priming

Hypothermic Preconditioning of Human Cortical Neurons Requires Proteostatic Priming

Hypothermia is potently neuroprotective but poor mechanistic understanding has restricted its clinical use. Rodent studies indicate that hypothermia can elicit preconditioning, wherein a subtoxic cellular stress confers resistance to an otherwise lethal injury. The molecular basis of this preconditi...

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Bibliographic Details
Main Authors: Nina Marie Rzechorzek, Peter Connick, Rickie Patani, Bhuvaneish Thangaraj Selvaraj, Siddharthan Chandran
Format: Article
Language:English
Published: Elsevier 2015-06-01
Series:EBioMedicine
Subjects:
Endoplasmic reticulum stress
Unfolded protein response
Hypothermia
Preconditioning
Proteostasis
Neuroprotection
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396415000985

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http://www.sciencedirect.com/science/article/pii/S2352396415000985

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