ZDHXB-101 (3′,5-Diallyl-2, 4′-dihydroxy-[1,1′-biphen-yl]-3,5′-dicarbaldehyde) protects against airway remodeling and hyperresponsiveness via inhibiting both the activation of the mitogen-activated protein kinase and the signal transducer and activator of transcription-3 signaling pathways

ZDHXB-101 (3′,5-Diallyl-2, 4′-dihydroxy-[1,1′-biphen-yl]-3,5′-dicarbaldehyde) protects against airway remodeling and hyperresponsiveness via inhibiting both the activation of the mitogen-activated protein kinase and the signal transducer and activator of transcription-3 signaling pathways

Abstract Airway remodeling consists of the structural changes of airway walls, which is often considered the result of longstanding airway inflammation, but it may be present to an equivalent degree in the airways of children with asthma, raising the need for early and specific therapeutic intervent...

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Bibliographic Details
Main Authors: Jun-xia Jiang, Hui-juan Shen, Yan Guan, Yong-liang Jia, Jian Shen, Qi Liu, Qiang-min Xie, Xiao-feng Yan
Format: Article
Language:English
Published: BMC 2020-01-01
Series:Respiratory Research
Subjects:
Epoxyeicosatrienoic acid
Soluble epoxide hydrolase
Asthma
Airway remodeling
Airway hyperresponsiveness
Online Access:https://doi.org/10.1186/s12931-020-1281-x

Internet

https://doi.org/10.1186/s12931-020-1281-x

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