Neuroprotective effects of an engineered Escherichia coli Nissle 1917 on Parkinson's disease in mice by delivering GLP‐1 and modulating gut microbiota

Neuroprotective effects of an engineered Escherichia coli Nissle 1917 on Parkinson's disease in mice by delivering GLP‐1 and modulating gut microbiota

Abstract Considerable evidence suggests that insulin resistance is closely linked to Parkinson's disease (PD), leading to agents aiming at treating diabetes can be regarded as new neuroprotective strategies in PD, notably glucagon‐like peptide‐1 (GLP‐1). However, the extremely short half‐life o...

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Bibliographic Details
Main Authors: Heng Wu, Jing Wei, Xiumiao Zhao, Ying Liu, Zhihang Chen, Kehong Wei, Jiachen Lu, Wenjie Chen, Meixiu Jiang, Shengjie Li, Tingtao Chen
Format: Article
Language:English
Published: Wiley 2023-09-01
Series:Bioengineering & Translational Medicine
Subjects:
E. coli Nissle 1917
genetically engineered strain
GLP‐1
gut microbiota
Parkinson's disease
Online Access:https://doi.org/10.1002/btm2.10351

Internet

https://doi.org/10.1002/btm2.10351

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