Structure-Based Design of Potent Peptidomimetic Inhibitors Covalently Targeting SARS-CoV-2 Papain-like Protease

Structure-Based Design of Potent Peptidomimetic Inhibitors Covalently Targeting SARS-CoV-2 Papain-like Protease

The papain-like protease (PL<sup>pro</sup>) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) plays a critical role in the proteolytic processing of viral polyproteins and the dysregulation of the host immune response, providing a promising therapeutic target. Here, we repo...

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Bibliographic Details
Main Authors: Qian Wang, Guofeng Chen, Jian He, Jiameng Li, Muya Xiong, Haixia Su, Minjun Li, Hangchen Hu, Yechun Xu
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:International Journal of Molecular Sciences
Subjects:
SARS-CoV-2
papain-like protease
covalent inhibitor
co-crystal structure
in vitro assay
Online Access:https://www.mdpi.com/1422-0067/24/10/8633

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https://www.mdpi.com/1422-0067/24/10/8633

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