Proximity proteomics identifies PAK4 as a component of Afadin–Nectin junctions
PAK4 is a kinase involved in cell-cell junctions, though the identify of the local protein network involving PAK4 is unclear. Here, the authors performed proximity proteomic analysis on mammalian PAK4 and find that PAK4 is associated with Afadin-dependent junctions, and report putative PAK4 phosph...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-25011-w |
| _version_ | 1831561979011006464 |
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| author | Yohendran Baskaran Felicia Pei-Ling Tay Elsa Yuen Wai Ng Claire Lee Foon Swa Sheena Wee Jayantha Gunaratne Edward Manser |
| author_facet | Yohendran Baskaran Felicia Pei-Ling Tay Elsa Yuen Wai Ng Claire Lee Foon Swa Sheena Wee Jayantha Gunaratne Edward Manser |
| author_sort | Yohendran Baskaran |
| collection | DOAJ |
| description | PAK4 is a kinase involved in cell-cell junctions, though the identify of the local protein network involving PAK4 is unclear. Here, the authors performed proximity proteomic analysis on mammalian PAK4 and find that PAK4 is associated with Afadin-dependent junctions, and report putative PAK4 phosphorylation substrates at this site. |
| first_indexed | 2024-12-17T10:30:36Z |
| format | Article |
| id | doaj.art-c9e161aeee0b4d8fb9c114a3126f6415 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-17T10:30:36Z |
| publishDate | 2021-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-c9e161aeee0b4d8fb9c114a3126f64152022-12-21T21:52:32ZengNature PortfolioNature Communications2041-17232021-09-0112111810.1038/s41467-021-25011-wProximity proteomics identifies PAK4 as a component of Afadin–Nectin junctionsYohendran Baskaran0Felicia Pei-Ling Tay1Elsa Yuen Wai Ng2Claire Lee Foon Swa3Sheena Wee4Jayantha Gunaratne5Edward Manser6sGSK Group, Institute of Molecular & Cell Biology, A*STARFB Laboratory, Institute of Molecular & Cell Biology, A*STARsGSK Group, Institute of Molecular & Cell Biology, A*STARQuantitative Proteomics Group, Institute of Molecular & Cell BiologyQuantitative Proteomics Group, Institute of Molecular & Cell BiologyQuantitative Proteomics Group, Institute of Molecular & Cell BiologysGSK Group, Institute of Molecular & Cell Biology, A*STARPAK4 is a kinase involved in cell-cell junctions, though the identify of the local protein network involving PAK4 is unclear. Here, the authors performed proximity proteomic analysis on mammalian PAK4 and find that PAK4 is associated with Afadin-dependent junctions, and report putative PAK4 phosphorylation substrates at this site.https://doi.org/10.1038/s41467-021-25011-w |
| spellingShingle | Yohendran Baskaran Felicia Pei-Ling Tay Elsa Yuen Wai Ng Claire Lee Foon Swa Sheena Wee Jayantha Gunaratne Edward Manser Proximity proteomics identifies PAK4 as a component of Afadin–Nectin junctions Nature Communications |
| title | Proximity proteomics identifies PAK4 as a component of Afadin–Nectin junctions |
| title_full | Proximity proteomics identifies PAK4 as a component of Afadin–Nectin junctions |
| title_fullStr | Proximity proteomics identifies PAK4 as a component of Afadin–Nectin junctions |
| title_full_unstemmed | Proximity proteomics identifies PAK4 as a component of Afadin–Nectin junctions |
| title_short | Proximity proteomics identifies PAK4 as a component of Afadin–Nectin junctions |
| title_sort | proximity proteomics identifies pak4 as a component of afadin nectin junctions |
| url | https://doi.org/10.1038/s41467-021-25011-w |
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