Evolutionary paths to macrolide resistance in a Neisseria commensal converge on ribosomal genes through short sequence duplications.

Evolutionary paths to macrolide resistance in a Neisseria commensal converge on ribosomal genes through short sequence duplications.

Neisseria commensals are an indisputable source of resistance for their pathogenic relatives. However, the evolutionary paths commensal species take to reduced susceptibility in this genus have been relatively underexplored. Here, we leverage in vitro selection as a powerful screen to identify the g...

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Bibliographic Details
Main Authors: Jordan C Raisman, Michael A Fiore, Lucille Tomin, Joseph K O Adjei, Virginia X Aswad, Jonathan Chu, Christina J Domondon, Ben A Donahue, Claudia A Masciotti, Connor G McGrath, Jo Melita, Paul A Podbielski, Madelyn R Schreiner, Lauren J Trumpore, Peter C Wengert, Emalee A Wrightstone, André O Hudson, Crista B Wadsworth
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0262370

Internet

https://doi.org/10.1371/journal.pone.0262370

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