Essential Amino Acid-Enriched Diet Alleviates Dexamethasone-Induced Loss of Muscle Mass and Function through Stimulation of Myofibrillar Protein Synthesis and Improves Glucose Metabolism in Mice

Essential Amino Acid-Enriched Diet Alleviates Dexamethasone-Induced Loss of Muscle Mass and Function through Stimulation of Myofibrillar Protein Synthesis and Improves Glucose Metabolism in Mice

Dexamethasone (DEX) induces dysregulation of protein turnover, leading to muscle atrophy and impairment of glucose metabolism. Positive protein balance, i.e., rate of protein synthesis exceeding rate of protein degradation, can be induced by dietary essential amino acids (EAAs). In this study, we in...

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Bibliographic Details
Main Authors: Yeongmin Kim, Sanghee Park, Jinseok Lee, Jiwoong Jang, Jiyeon Jung, Jin-Ho Koh, Cheol Soo Choi, Robert R. Wolfe, Il-Young Kim
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Metabolites
Subjects:
dexamethasone
muscle atrophy
essential amino acids
protein turnover
glucose metabolic flux
Online Access:https://www.mdpi.com/2218-1989/12/1/84

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https://www.mdpi.com/2218-1989/12/1/84

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