Glucose metabolic upregulation via phosphorylation of S6 ribosomal protein affects tumor progression in distal cholangiocarcinoma

Glucose metabolic upregulation via phosphorylation of S6 ribosomal protein affects tumor progression in distal cholangiocarcinoma

Abstract Background The prognosis of distal cholangiocarcinoma (dCCA) remains poor; thus, the identification of new therapeutic targets is warranted. Phosphorylated S6 ribosomal protein indicates a mammalian target of rapamycin complex 1 (mTORC1) activity, and mTORC1 plays a central role in controll...

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Bibliographic Details
Main Authors: Atsuro Fujinaga, Teijiro Hirashita, Yuka Hirashita, Kumiko Sakai, Masahiro Kawamura, Takashi Masuda, Yuichi Endo, Masayuki Ohta, Kazunari Murakami, Masafumi Inomata
Format: Article
Language:English
Published: BMC 2023-05-01
Series:BMC Gastroenterology
Subjects:
Distal cholangiocarcinoma
Mammalian target of rapamycin complex 1
Glucose transporter 1
Phosphorylated S6 ribosomal protein
Glycolysis
Online Access:https://doi.org/10.1186/s12876-023-02815-2

Internet

https://doi.org/10.1186/s12876-023-02815-2

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