Divergent Cl- and H+ pathways underlie transport coupling and gating in CLC exchangers and channels

Divergent Cl- and H+ pathways underlie transport coupling and gating in CLC exchangers and channels

The CLC family comprises H+-coupled exchangers and Cl- channels, and mutations causing their dysfunction lead to genetic disorders. The CLC exchangers, unlike canonical 'ping-pong' antiporters, simultaneously bind and translocate substrates through partially congruent pathways. How ions of...

Cur síos iomlán

Sonraí bibleagrafaíochta
Príomhchruthaitheoirí: Lilia Leisle, Yanyan Xu, Eva Fortea, Sangyun Lee, Jason D Galpin, Malvin Vien, Christopher A Ahern, Alessio Accardi, Simon Bernèche
Formáid: Alt
Teanga:English
Foilsithe / Cruthaithe: eLife Sciences Publications Ltd 2020-04-01
Sraith:eLife
Ábhair:
active transport
membrane protein
ion channels
Rochtain ar líne:https://elifesciences.org/articles/51224

Ar líne

https://elifesciences.org/articles/51224

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