Loss of FoxOs in muscle increases strength and mitochondrial function during aging

Loss of FoxOs in muscle increases strength and mitochondrial function during aging

Abstract Background Muscle mitochondrial decline is associated with aging‐related muscle weakness and insulin resistance. FoxO transcription factors are targets of insulin action and deletion of FoxOs improves mitochondrial function in diabetes. However, disruptions in proteostasis and autophagy are...

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Bibliographic Details
Main Authors: Christie M. Penniman, Gourav Bhardwaj, Colette J. Nowers, Chandler U. Brown, Taylor L. Junck, Cierra K. Boyer, Jayashree Jena, Jordan D. Fuqua, Vitor A. Lira, Brian T. O'Neill
Format: Article
Language:English
Published: Wiley 2023-02-01
Series:Journal of Cachexia, Sarcopenia and Muscle
Subjects:
FoxO
Aging
Mitochondrial function
Insulin resistance
Muscle hypertrophy
Glucose tolerance
Online Access:https://doi.org/10.1002/jcsm.13124

Internet

https://doi.org/10.1002/jcsm.13124

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