Loss of FoxOs in muscle increases strength and mitochondrial function during aging

Loss of FoxOs in muscle increases strength and mitochondrial function during aging

Abstract Background Muscle mitochondrial decline is associated with aging‐related muscle weakness and insulin resistance. FoxO transcription factors are targets of insulin action and deletion of FoxOs improves mitochondrial function in diabetes. However, disruptions in proteostasis and autophagy are...

Deskribapen osoa

Xehetasun bibliografikoak
Egile Nagusiak: Christie M. Penniman, Gourav Bhardwaj, Colette J. Nowers, Chandler U. Brown, Taylor L. Junck, Cierra K. Boyer, Jayashree Jena, Jordan D. Fuqua, Vitor A. Lira, Brian T. O'Neill
Formatua: Artikulua
Hizkuntza:English
Argitaratua: Wiley 2023-02-01
Saila:Journal of Cachexia, Sarcopenia and Muscle
Gaiak:
FoxO
Aging
Mitochondrial function
Insulin resistance
Muscle hypertrophy
Glucose tolerance
Sarrera elektronikoa:https://doi.org/10.1002/jcsm.13124

Internet

https://doi.org/10.1002/jcsm.13124

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