Establishment and Characterization of <i>hTERT</i> Immortalized Hutchinson–Gilford Progeria Fibroblast Cell Lines

Establishment and Characterization of <i>hTERT</i> Immortalized Hutchinson–Gilford Progeria Fibroblast Cell Lines

Hutchinson–Gilford progeria syndrome (HGPS) is a rare premature aging syndrome caused by a dominant mutation in the <i>LMNA</i> gene. Previous research has shown that the ectopic expression of the catalytic subunit of telomerase (<i>hTERT</i>) can elongate the telomeres of th...

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Bibliographic Details
Main Authors: Haihuan Lin, Juliane Mensch, Maria Haschke, Kathrin Jäger, Brigitte Köttgen, Jens Dernedde, Evelyn Orsó, Michael Walter
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Cells
Subjects:
Hutchinson–Gilford progeria syndrome (HGPS)
telomerase
telomere length
cell senescence
β-galactosidase
Online Access:https://www.mdpi.com/2073-4409/11/18/2784

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https://www.mdpi.com/2073-4409/11/18/2784

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