Human ApoE2 protects mice against Plasmodium berghei ANKA experimental cerebral malaria

Human ApoE2 protects mice against Plasmodium berghei ANKA experimental cerebral malaria

ABSTRACTCerebral malaria (CM) is a severe neurological complication of Plasmodium falciparum infection with acute brain lesions. Genetic variations in both host and parasite have been associated with susceptibility to CM, but the underlying molecular mechanism remains unclear. Here, we demonstrate t...

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Bibliographic Details
Main Authors: Rui Liang, Hengjun Rao, Qin Pang, Ruixue Xu, Zhiwei Jiao, Lirong Lin, Li Li, Li Zhong, Yixin Zhang, Yazhen Guo, Nengming Xiao, Shengfa Liu, Xiao-Fen Chen, Xin-zhuan Su, Jian Li
Format: Article
Language:English
Published: American Society for Microbiology 2023-12-01
Series:mBio
Subjects:
apolipoprotein E
lipid metabolism
immune response
blood-brain barrier
transcriptome
Online Access:https://journals.asm.org/doi/10.1128/mbio.02346-23

Internet

https://journals.asm.org/doi/10.1128/mbio.02346-23

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