A One-Step Sample Processing Method in Combination with HPLC-MS/MS for the Simultaneous Quantification of Atorvastatin, Ezetimibe and Three Metabolites including <i>o</i>-Hydroxyl Atorvastatin, <i>p</i>-Hydroxyl Atorvastatin, and Ezetimibe-Glucuronide in Human Plasma

A One-Step Sample Processing Method in Combination with HPLC-MS/MS for the Simultaneous Quantification of Atorvastatin, Ezetimibe and Three Metabolites including <i>o</i>-Hydroxyl Atorvastatin, <i>p</i>-Hydroxyl Atorvastatin, and Ezetimibe-Glucuronide in Human Plasma

A simple and sensitive liquid chromatography–tandem mass spectrometry (LC-MS/MS) method has been developed for the simultaneous determination of atorvastatin (ATOR), ezetimibe (EZM), and their three metabolites, including <i>o</i>-hydroxyl atorvastatin (<i>o</i>-OH ATOR), <...

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Bibliographic Details
Main Authors: T. Nguyen Nguyen Le, Nai Ngoc Chuong, Tuan Duc Nguyen
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Separations
Subjects:
atorvastatin
ezetimibe
<i>o</i>-hydroxyl atorvastatin
<i>p</i>-hydroxyl atorvastatin
ezetimibe–glucuronide
LC-MS/MS
Online Access:https://www.mdpi.com/2297-8739/10/7/409

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