Hypoxic mesenchymal stem cell-derived exosomes promote the survival of skin flaps after ischaemia–reperfusion injury via mTOR/ULK1/FUNDC1 pathways

Hypoxic mesenchymal stem cell-derived exosomes promote the survival of skin flaps after ischaemia–reperfusion injury via mTOR/ULK1/FUNDC1 pathways

Abstract Flap necrosis, the most prevalent postoperative complication of reconstructive surgery, is significantly associated with ischaemia–reperfusion injury. Recent research indicates that exosomes derived from bone marrow mesenchymal stem cells (BMSCs) hold potential therapeutic applications in s...

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Bibliographic Details
Main Authors: Chao Deng, Kangkang Dong, Yongjun Liu, Ken Chen, Chuwei Min, Zheming Cao, Panfeng Wu, Gaojie Luo, Gechang Cheng, Liming Qing, Juyu Tang
Format: Article
Language:English
Published: BMC 2023-09-01
Series:Journal of Nanobiotechnology
Subjects:
Exosomes
Hypoxia
Bone marrow mesenchymal stem cells
Ischaemia–reperfusion
Skin flap
miRNA
Online Access:https://doi.org/10.1186/s12951-023-02098-5

Internet

https://doi.org/10.1186/s12951-023-02098-5

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