ExoU Induces Lung Endothelial Cell Damage and Activates Pro-Inflammatory Caspase-1 during <i>Pseudomonas aeruginosa</i> Infection

ExoU Induces Lung Endothelial Cell Damage and Activates Pro-Inflammatory Caspase-1 during <i>Pseudomonas aeruginosa</i> Infection

The Gram-negative, opportunistic pathogen <i>Pseudomonas aeruginosa</i> utilizes a type III secretion system to inject exoenzyme effectors into a target host cell. Of the four best-studied exoenzymes, ExoU causes rapid cell damage and death. ExoU is a phospholipase A<sub>2</sub&...

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Bibliographic Details
Main Authors: Kierra S. Hardy, Amanda N. Tuckey, Phoibe Renema, Mita Patel, Abu-Bakr Al-Mehdi, Domenico Spadafora, Cody A. Schlumpf, Robert A. Barrington, Mikhail F. Alexeyev, Troy Stevens, Jean-Francois Pittet, Brant M. Wagener, Jon D. Simmons, Diego F. Alvarez, Jonathon P. Audia
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Toxins
Subjects:
<i>Pseudomonas aeruginosa</i>
ExoU
pulmonary endothelial cells
caspase-1
mitochondria
pneumonia
Online Access:https://www.mdpi.com/2072-6651/14/2/152

Internet

https://www.mdpi.com/2072-6651/14/2/152

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