Role of hydrophobic side chain in urea induced protein denaturation at interface

The molecular mechanism of denaturing ability of urea is still a subject of considerable debate due to two opposing mechanisms: direct and indirect. In the direct mechanism, urea directly disrupts hydrogen bonding and hydrophobic interactions within proteins. On the other hand, the indirect mechanis...

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Bibliographic Details
Main Authors: Preeti Gahtori, Vineet Gunwant, Ravindra Pandey
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Chemical Physics Impact
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2667022423001536