GSDME has prognostic and immunotherapeutic significance in residual hepatocellular carcinoma after insufficient radiofrequency ablation

GSDME has prognostic and immunotherapeutic significance in residual hepatocellular carcinoma after insufficient radiofrequency ablation

Background: Heat stress can induce programmed cell death (PCD). Pyroptosis is a gasdermin-mediated PCD. This study hypothesized that insufficient radiofrequency ablation (IRFA) induced pyroptosis in hepatocellular carcinoma (HCC) and investigated its underlying mechanism and clinical significance. M...

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Bibliographic Details
Main Authors: Xuexia Liang, Qiaodan Liu, Shuqin Zhu, Zizi Li, Hui Chen, Zhongzhen Su
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Translational Oncology
Subjects:
Hepatocellular carcinoma
Insufficient radiofrequency ablation
GSDME
Exhausted T cell
PD-L1 inhibitor
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523323001821

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http://www.sciencedirect.com/science/article/pii/S1936523323001821

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