Role of cationic drug-sensitive transport systems at the blood-cerebrospinal fluid barrier in para-tyramine elimination from rat brain

Abstract Background para-Tyramine (p-TA) is a biogenic amine which is involved in multiple neuronal signal transductions. Since the concentration of p-TA in dog cerebrospinal fluid (CSF) has been reported to be greater than that in plasma, it is proposed that clearance of cerebral p-TA is important...

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Bibliographic Details
Main Authors: Shin-ichi Akanuma, Yuhei Yamazaki, Yoshiyuki Kubo, Ken-ichi Hosoya
Format: Article
Language:English
Published: BMC 2018-01-01
Series:Fluids and Barriers of the CNS
Subjects:
Online Access:http://link.springer.com/article/10.1186/s12987-017-0087-9