Preliminary investigation of deoxyoligonucleotide binding to ribonuclease A using mass spectrometry: An attempt to develop a lab experience for undergraduates [version 2; referees: 2 approved]

Deoxyoligonucleotide binding to bovine pancreatic ribonuclease A (RNase A) was investigated using electrospray ionization ion-trap mass spectrometry (ESI-IT-MS). Deoxyoligonucleotides included CCCCC (dC5) and CCACC (dC2AC2).  This work was an attempt to develop a biochemistry lab experience that wou...

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Bibliographic Details
Main Author: Daniel D. Clark
Format: Article
Language:English
Published: F1000 Research Ltd 2018-04-01
Series:F1000Research
Online Access:https://f1000research.com/articles/7-340/v2