Effect of dapagliflozin on ferroptosis through the gut microbiota metabolite TMAO during myocardial ischemia–reperfusion injury in diabetes mellitus rats

Effect of dapagliflozin on ferroptosis through the gut microbiota metabolite TMAO during myocardial ischemia–reperfusion injury in diabetes mellitus rats

Abstract Dapagliflozin (DAPA) demonstrates promise in the management of diabetic mellitus (DM) and cardiomyopathy. Trimethylamine N-oxide (TMAO) is synthesized by the gut microbiota through the metabolic conversion of choline and phosphatidylcholine. Ferroptosis may offer novel therapeutic avenues f...

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Bibliographic Details
Main Authors: Lian Wang, Yao Wang, Heng Xu, Wenyuan Li
Format: Article
Language:English
Published: Nature Portfolio 2024-06-01
Series:Scientific Reports
Subjects:
Diabetes
Myocardial ischemia/reperfusion
Dapagliflozin
Trimethylamine N-oxide
Ferroptosis
Molecular docking
Online Access:https://doi.org/10.1038/s41598-024-64909-5

Internet

https://doi.org/10.1038/s41598-024-64909-5

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