Laropiprant attenuates EP3 and TP prostanoid receptor-mediated thrombus formation.

Laropiprant attenuates EP3 and TP prostanoid receptor-mediated thrombus formation.

The use of the lipid lowering agent niacin is hampered by a frequent flush response which is largely mediated by prostaglandin (PG) D(2). Therefore, concomitant administration of the D-type prostanoid (DP) receptor antagonist laropiprant has been proposed to be a useful approach in preventing niacin...

Full description

Bibliographic Details
Main Authors: Sonia Philipose, Viktoria Konya, Mirjana Lazarevic, Lisa M Pasterk, Gunther Marsche, Sasa Frank, Bernhard A Peskar, Akos Heinemann, Rufina Schuligoi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3411562?pdf=render

Internet

http://europepmc.org/articles/PMC3411562?pdf=render

Similar Items