Identification and Phenotypic Characterization of Hsp90 Phosphorylation Sites That Modulate Virulence Traits in the Major Human Fungal Pathogen Candida albicans

Identification and Phenotypic Characterization of Hsp90 Phosphorylation Sites That Modulate Virulence Traits in the Major Human Fungal Pathogen Candida albicans

The highly conserved, ubiquitous molecular chaperone Hsp90 is a key regulator of cellular proteostasis and environmental stress responses. In human pathogenic fungi, which kill more than 1.6 million patients each year worldwide, Hsp90 governs cellular morphogenesis, drug resistance, and virulence. Y...

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Bibliographic Details
Main Authors: Leenah Alaalm, Julia L. Crunden, Mark Butcher, Ulrike Obst, Ryann Whealy, Carolyn E. Williamson, Heath E. O’Brien, Christiane Schaffitzel, Gordon Ramage, James Spencer, Stephanie Diezmann
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
fungal virulence
phospho-switch
Hsp90
thermotolerance
drug response
morphogenesis
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2021.637836/full

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https://www.frontiersin.org/articles/10.3389/fcimb.2021.637836/full

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