An Extended C-Terminus, the Possible Culprit for Differential Regulation of 5-Aminolevulinate Synthase Isoforms

An Extended C-Terminus, the Possible Culprit for Differential Regulation of 5-Aminolevulinate Synthase Isoforms

5-Aminolevulinate synthase (ALAS; E.C. 2.3.1.37) is a pyridoxal 5′-phosphate (PLP)-dependent enzyme that catalyzes the key regulatory step of porphyrin biosynthesis in metazoa, fungi, and α-proteobacteria. ALAS is evolutionarily related to transaminases and is therefore classified as a fold type I P...

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Bibliographic Details
Main Authors: Gregory A. Hunter, Gloria C. Ferreira
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Molecular Biosciences
Subjects:
5-aminolevulinate synthase
pyridoxal 5′-phosphate
heme regulatory motif
allostery
redox sensor
porphyrin
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2022.920668/full

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https://www.frontiersin.org/articles/10.3389/fmolb.2022.920668/full

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