Unveiling a CAAX Protease‐Like Protein Involved in Didemnin Drug Maturation and Secretion

Unveiling a CAAX Protease‐Like Protein Involved in Didemnin Drug Maturation and Secretion

Abstract The assembly line biosynthesis of the powerful anticancer‐antiviral didemnin cyclic peptides is proposed to follow a prodrug release mechanism in Tristella bacteria. This strategy commences with the formation of N‐terminal prodrug scaffolds and culminates in their cleavage during the cellul...

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Bibliographic Details
Main Authors: Xiaolin Zou, Zhen Hui, Robert A. Shepherd, Shuaiqiang Zhao, Yanfei Wu, Zhuanglin Shen, Cuiping Pang, Shipeng Zhou, Zehai Yu, Jiahai Zhou, Bradley S. Moore, Laura M. Sanchez, Xiaoyu Tang
Format: Article
Language:English
Published: Wiley 2024-01-01
Series:Advanced Science
Subjects:
biosynthesis
CAAX proteases
didemnins
nonribosomal peptide synthetase (NRPS)
prodrug mechanism
Online Access:https://doi.org/10.1002/advs.202306044

Internet

https://doi.org/10.1002/advs.202306044

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