Effects of Formulation and Process Variables on Gastroretentive Floating Tablets with A High-Dose Soluble Drug and Experimental Design Approach

Effects of Formulation and Process Variables on Gastroretentive Floating Tablets with A High-Dose Soluble Drug and Experimental Design Approach

To develop sustained release gastro-retentive effervescent floating tablets (EFT), a quality-based experimental design approach was utilized during the composing of a hydrophilic matrix loaded with a high amount of a highly water-soluble model drug, metformin HCl. Effects of the amount of polyethyle...

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Bibliographic Details
Main Authors: Prakash Thapa, Seong Hoon Jeong
Format: Article
Language:English
Published: MDPI AG 2018-09-01
Series:Pharmaceutics
Subjects:
polyethylene oxide
sodium bicarbonate
gel strength
floating lag time
drug release kinetics
experimental design
Online Access:http://www.mdpi.com/1999-4923/10/3/161

Internet

http://www.mdpi.com/1999-4923/10/3/161

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