Degradation of Mutant Protein Aggregates within the Endoplasmic Reticulum of Vasopressin Neurons

Degradation of Mutant Protein Aggregates within the Endoplasmic Reticulum of Vasopressin Neurons

Summary: Misfolded or unfolded proteins in the ER are said to be degraded only after translocation or isolation from the ER. Here, we describe a mechanism by which mutant proteins are degraded within the ER. Aggregates of mutant arginine vasopressin (AVP) precursor were confined to ER-associated com...

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Bibliographic Details
Main Authors: Takashi Miyata, Daisuke Hagiwara, Yuichi Hodai, Tsutomu Miwata, Yohei Kawaguchi, Junki Kurimoto, Hajime Ozaki, Kazuki Mitsumoto, Hiroshi Takagi, Hidetaka Suga, Tomoko Kobayashi, Mariko Sugiyama, Takeshi Onoue, Yoshihiro Ito, Shintaro Iwama, Ryoichi Banno, Mami Matsumoto, Natsuko Kawakami, Nobuhiko Ohno, Hirotaka Sakamoto, Hiroshi Arima
Format: Article
Language:English
Published: Elsevier 2020-10-01
Series:iScience
Subjects:
neuroscience
cell biology
technical aspects of cell biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220308403

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http://www.sciencedirect.com/science/article/pii/S2589004220308403

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