Spinal microglia contribute to sustained inflammatory pain via amplifying neuronal activity

Spinal microglia contribute to sustained inflammatory pain via amplifying neuronal activity

Abstract Microglia are highly dynamic immune cells of the central nervous system (CNS). Microglial processes interact with neuronal elements constantly on the order of minutes. The functional significance of this acute microglia-neuron interaction and its potential role in the context of pain is sti...

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Bibliographic Details
Main Authors: Nan Gu, Min-Hee Yi, Madhuvika Murugan, Manling Xie, Sebastian Parusel, Jiyun Peng, Ukpong B. Eyo, Christine L. Hunt, Hailong Dong, Long-Jun Wu
Format: Article
Language:English
Published: BMC 2022-10-01
Series:Molecular Brain
Subjects:
Microglia
Microglia–neuron interaction
Inflammatory pain
Formalin
P2Y12 receptor
Two-photon imaging
Online Access:https://doi.org/10.1186/s13041-022-00970-3

Internet

https://doi.org/10.1186/s13041-022-00970-3

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