Evaluation of Suitable Polymeric Matrix/Carriers during Loading of Poorly Water Soluble Drugs onto Mesoporous Silica: Physical Stability and In Vitro Supersaturation

Evaluation of Suitable Polymeric Matrix/Carriers during Loading of Poorly Water Soluble Drugs onto Mesoporous Silica: Physical Stability and In Vitro Supersaturation

The application of mesoporous carriers in formulations of amorphous solid dispersions (ASDs) has been suggested to enhance the stability of amorphous drugs. However, mesoporous carriers do not demonstrate satisfactory inhibitory effects on the precipitation of active pharmaceutical ingredients (APIs...

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Bibliographic Details
Main Authors: Afroditi Kapourani, Konstantinos Katopodis, Vasiliki Valkanioti, Melina Chatzitheodoridou, Christos Cholevas, Panagiotis Barmpalexis
Format: Article
Language:English
Published: MDPI AG 2024-03-01
Series:Polymers
Subjects:
amorphous solid dispersions
mesoporous carriers
Syloid 244 FP
sustained supersaturation
physical stability
Online Access:https://www.mdpi.com/2073-4360/16/6/802

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https://www.mdpi.com/2073-4360/16/6/802

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